A book chapter with Prof. Shoumo Bhattacharya “Using evasins to target the chemokine network in inflammation” published in Advances in Protein Chemistry and Structural Biology is out now.
Delighted to contribute two chapters in Chemical Epigenetics in Topics in Medicinal Chemistry book series edited by Prof. Antonello Mai. Our review on “Inhibitors of JmjC-containing Histone Demethylases” by Miranda Wright, together with Prof. Paul Brennan (Target Discovery Institute, Oxford), focuses on the recent advances in JmjC-KDM inhibitor development from a structural perspective. In “Chemical Compounds Targeting DNA Methylation and Hydroxymethylation” by Roman Bell, together with Dr Paola Arimondo (Institut Pasteur, Paris), we review the recent developments in DNMT and TET inhibitors.
I was very pleased to have the opportunity to talk at the CBBG forum in Leicester at the Institute of Structural and Chemical Biology, very well co-organised by former Oxford colleague Richard Hopkinson. I spoke about our work on cyclic peptides binding to PHD2, as published in Chemical Science, and some more recent follow-up work. This was a great meeting; an excellent day of Chemical Biology talks and posters, as well as a chance to network, catching up with some people I already knew and making some new contacts. (Blog by Tom McAllister)
Paper in Oncogene – Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. Our collaborative work with Dr Nathan Lack’s laboratory (Koç University / Turkey and Vancouver Prostate Centre /Canada) is finally out! Hilal Saraç has led this study on how KDM3B has been identified to be important in the proliferation of castrate resistant prostate cancers. This work was funded by the Royal Society Newton Advance Fellowship. Hilal’s beautiful waterfall plot figure – epigenetic shRNA library screening identifies KDM3B (red) to be essential for CRPC proliferation
We enjoyed our traditional Kawamura-Flashman Group joint Christmas lunch
After a few long days of packing the labs in Oxford, it was lovely to see so many people from the CRL come together for a few drinks and a relax at the Oxford Wine Café – including old group members – thank you for joining us!
Many Congratulations to Roman Belle for successfully defending his DPhil thesis titled “Histone Lysine and DNA Methylation: Dynamic Marks in the Chromatin”! Thanks to Dr Paola Arimondo from Institute Pasteur and James McCullagh for being his examiners.
Very honoured to speak at the GSK Emerging Academics Symposium 2019. Great to meet GSK scientists and UK academics, and to have the opportunity to present our work on epigenetic chemical probes.
We had a fantastic day engaging with members of the public and talking about Epigenetics at the Oxford Science + Ideas festival. Children enjoyed modifying our plasticine histone model, and everyone appreciated real world examples of how Epigenetics is an important area of research. We showed people that identical twins differ because of the different environments they experience, using NASA twins Scott and Mark Kelly as a unique example of two very different environments! We also found some great examples of how Epigenetics affects animals: bees have completely different roles based on their diet during development, and that the sex of some species of turtles differ depending on the temperature… Read More »Epigenetics exhibit at the Oxford Science + Ideas Festival
