Welcome

Research in the Kawamura group centres on applying chemical biology approaches to understanding and modulating biological processes of interest.

Latest Publications

Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic protein. R. Belle, J. J. A. G. Kamps, J. Poater, K. Kumar, B. J. G. E. Pieters, E. Salah, T. D. W. Claridge, R. S. Paton, F. M. Bickelhaupt, A. Kawamura, C. J. Schofield, J. Mecinović; Commun.  J. Commun. Chem (2022) https://doi.org/10.1038/s42004-022-00640-4 [Web] [PDF]

An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor.  Bhaskar Bhushan, Daniele Granata, Christian S. Kaas, Marina A. Kasimova, Qiansheng Ren, Christian N. Cramer,  Mark D. White, Ann Maria K. Hansen,Christian Fledelius, Gaetano Invernizzi,Kristine Deibler, Oliver D. Coleman, Xin Zhao, Xinping Qu, Haimo Liu, Silvana S. Zurmühl,b Janos T. Kodra, Akane Kawamura and Martin Münzel Chem. Sci., 2022, Advance Article DOI: https://doi.org/10.1039/D1SC06844J [Web]

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. Radosław P. Nowak, Anthony Tumber, Eline Hendrix, Mohammad Salik Zeya Ansari, Manuela Sabatino, Lorenzo Antonini, Regina Andrijes, Eidarus Salah, Nicola Mautone, Francesca Romana Pellegrini, Klemensas Simelis, Akane Kawamura, Catrine Johansson, Daniela Passeri, Roberto Pellicciari, Alessia Ciogli, Donatella Del Bufalo, Rino Ragno, Mathew L. Coleman, Daniela Trisciuoglio, Antonello Mai, Udo Oppermann, Christopher J. Schofield, and Dante Rotili J. Med. Chem (2021) 64, 23, 17031–17050 doi: https://doi.org/10.1021/acs.jmedchem.1c00605 [Web] [PDF]

JMJD6 is a druggable oxygenase that regulates AR-V7 expression in prostate cancer. Alec Paschalis, Jonathan Welti, Antje J. Neeb, Wei Yuan, Ines Figueiredo, Rita Pereira, Ana Ferreira, Ruth Riisnaes, Daniel Nava Rodrigue, Juan M. Jiménez-Vacas, Soojin Kim, Takuma Uo, Patrizio Di Micco, Anthony Tumber, Md. Saiful Islam, Marc A. Moesser, Martine Abboud, Akane Kawamura, Bora Gurel, Rossitza Christova, Veronica S. Gil, Lorenzo Buroni, Mateus Crespo, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Nina Tunariu, Andrea Alimonti, SU2C/PCF International Prostate Cancer Dream Team Bissan Al-Lazikani, Christopher J. Schofield, Stephen R. Plymate, Adam Sharp, Johann S. de Bono, Cancer Res (2021) 81 (4): 1087–1100. https://doi.org/10.1158/0008-5472.CAN-20-1807 [Web] [PDF]

Book chapter: The Discovery and Utility of Chemical Probes in Target Discovery
Editors: Paul Brennan, Saleta Vazquez Rodriguez
L. Serrano, G. Roper and A. Kawamura, CHAPTER 5: Cyclic Peptides as Chemical Probes , in The Discovery and Utility of Chemical Probes in Target Discovery (2020) pp. 100-123 DOI: 10.1039/9781839160745-00100
eISBN: 978-1-83916-074-5
[Web] [PDF]

Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction. Darlot B, Eaton JRO, Geis-Asteggiante L, Yakala GK, Karuppanan K, Davies G, Robinson CV, Kawamura A and Bhattacharya S. J Biol Chem (2020) Doi: 10.1074/jbc.RA120.014103 [web][PDF]

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications. Hsu KF, Wilkins SE, Hopkinson RJ, Sekirnik R, Flashman E, Kawamura A, McCullagh JSO, Walport L, Schofield CJ. Epigenetics (2020) doi: 10.1080/15592294.2020.1786305 [web][PDF]

Research Funding