Research in the Kawamura group centres on applying chemical biology approaches to understanding and modulating biological processes of interest.
Latest Publications
Active learning driven prioritisation of compounds from on-demand libraries targeting the SARS-CoV-2 main protease. Cree B, Bieniek MK, Amin S, Kawamura A, Cole DJ. Digital Discovery (2025). https://doi.org/10.1039/D4DD00343H [web]
JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships. Bonnici J, Oueini R, Salah E, Johansson C, Pires E, Abboud M, Dawber RS, Tumber A, Rabe P, Saraç H, Schofield CJ, Kawamura A. Communications Biology (2024) https://doi.org/10.1038/s42003-024-07183-5 [web]
Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling. Šimelis K, Saraç H, Salah E, Nishio K, McAllister TE, Corner TP, Tumber A, Belle R, Schofield CJ, Suga H, Kawamura A. Bioorganic & Medicinal Chemistry (2024) https://doi.org/10.1016/j.bmc.2024.117597 [Web]
Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis. Smith TP, Bhaskar Bhushan B, Granata D, Kaas C, Andersen B, Decoene K, Ren Q, Liu H, Qu X, Yang Y, Pan J, Chen Q, Münzel M, Kawamura A. RSC Chemical Biology (2023) https://doi.org/10.1039/d3cb00168g [Web]
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Belle R, Saraç H, Salah E, Bhushan B, Szykowska A, Roper G, Tumber A, Kriaucionis S, Burgess-Brown N, Schofield CJ, Brown T, Kawamura A. Journal of Medicinal Chemistry (2024) https://doi.org/10.1021/acs.jmedchem.3c01820 [Web]
for more see Publications
Chemical Biology at Newcastle University
Chemical biology is a multidisciplinary field that lies at the intersection of chemistry and, biology, and medicine. This explainer video explains more and provides an insight into what chemical biology research is taking place at Newcastle University:
Research Funding
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