On Friday 1st July 2022 we hosted the second Chemical biology workshop at Newcastle University Groups from across the faculty of medicine science and the school of natural and environment science presented a quick synopsis of their research with the aim to spark ideas for collaboration and more awareness of the diverse Chem Bio research happening at Newcastle University. Ten academics delivered flash presentations on diverse areas of research (see below). The talks were followed by a poster session where our early career researchers showcased their work and networked with colleagues from across the university. Exploring mechanisms of kinase inhibitor resistance in MYC driven lymphoma, Neil Perkins, FMS Understanding protein… Read More »Summer Newcastle University Chemical Biology Workshop
A warm welcome to Harriet Stanway-Gordon who started in the group this month. Harriet undertook her PhD with Prof. Mike Waring in the Medicinal Chemistry group at Newcastle, focusing on the development of micellar-mediated DNA-compatible chemistry for use in DNA-encoded library (DEL) synthesis, where she was involved in the development and optimisation of multiple classes of reactions. Through the application of this methodology, a proposed new class of drug molecules, termed cyclic peptide small molecule hybrids (CyPeMs) can now be constructed within DELs. Harriet has been awarded an EPSRC doctoral prize to expand upon her PhD research, involving the synthesis of CyPeM DELs and subsequent selection against several challenging epigenetic… Read More »Welcome to the group Harriet!
Our group member Klemensas Simelis based at Oxford University handed in his thesis this week. Klem’s research looked at the “Development of Chemical Tools for Ten-Eleven Translocation Enzymes”. A summary of his project follows: Methylation of DNA (5-methylcytosine) is an epigenetic mark that typically silences gene expression. Ten-Eleven Translocation enzymes (TETs) oxidise the methyl groups of 5-methylcytosine, forming epigenetic DNA marks with distinct functions and facilitating DNA demethylation by other cellular mechanisms, which restores gene expression. The work discussed in the thesis is focused on: i) broadening the understanding of how these enzymes work using biochemical assays to detect catalytic activity, and ii) developing small molecule and cyclic peptide TET inhibitors… Read More »Thesis hand in day for Klem!
Kawamura group PhD student Grace Roper attended the RSC Chemical Biology Symposium which took place in London on 9th May 2022. Grace presented her work in collaboration with GSK with a poster on ‘macrocyclic peptides as affinity probes’. Some brilliant talks and opportunities for networking, Grace really enjoyed catching up with colleagues from the Oxford-GSK-Crick CDT.
Many congratulations to group member Grace Roper and her husband Cameron Taylor (a medicinal chemist!) on their wedding! Thanks for inviting us to share your day. We wish these two wonderfully talented scientists all the best!
Delighted to host our CRUK Programme meeting in-person after our last meeting was cancelled due to COVID19. The meeting took place at Newcastle University on Friday 29th April 2022. Thank you to Prof Chris Schofield and the Oxford team for traveling up to Newcastle, wonderful to catch-up with our Oxford colleagues! We had such a productive time discussing science/ progress of our CRUK work and meeting with the CRUK Newcastle Drug Discovery team. Looking forward to our next meeting in Oxford!
Some great talks and networking at the Royal Society of Chemistry Interest Group for Chemical Biology and Bioorganic Chemistry postgraduate meeting at York University on 4th April. Great to be back to in-person conferences! It was a great opportunity for our early career researchers to share their latest research with colleagues from across a broad range of chemical biology backgrounds.
We are delighted to announce that Chiara Maniaci has been selected to attend the prestigious 71st Lindau Nobel Laureate Meeting in June. Chiara will join a cohort of 611 of the most qualified young scientists from 91 countries after a rigorous selection process. She was nominated by the Royal Society and assessed on academic ability, motivation, and extra-curricular activities in a multi-stage process. The meeting will take place in Lindau, Germany from 26 June – 1 July, the participants will be able to meet each other and around 30 Nobel Laureates in person. The Lindau Nobel Laureate Meetings foster the exchange among scientists of different generations, cultures, and disciplines. Chiara… Read More »Chiara selected to attend the Lindau Nobel Laureate Meeting!
On Tuesday 15th March we hosted a Chemical biology workshop at Newcastle University, involving academics across the faculty of medicine science and the school of natural and environment science. Ten academics delivered flash presentations on diverse areas of research (see below). A great way to get the group talking and learning about the chemical biology research going on across the university. Engineered protein polymers for high performance, multi-functional biomaterials Daniel Peters and David A Fulton Structure guided drug discovery for loss-of-function diseases Wyatt Yue (Cyclic) peptide discovery platform Akane Kawamura In vivo Non-invasive Small Animal Molecular Imaging Services Saimir Luli Mass spectrometry tools in drug discovery Matthias Trost Biocatalysts… Read More »Chemical Biology Workshop
Delighted to share the first publication of our collaboration with Martin Munzel and colleagues at NovoNordisk ‘An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor‘. Thanks to all involved: Bhaskar Bhushan, Daniele Granata, Christian S. Kaas, Marina A. Kasimova, Qiansheng Ren, Christian N. Cramer, Mark D. White, Ann Maria K. Hansen,Christian Fledelius, Gaetano Invernizzi,Kristine Deibler, Oliver D. Coleman, Xin Zhao, Xinping Qu, Haimo Liu, Silvana S. Zurmühl,b Janos T. Kodra, Akane Kawamura and Martin Münzel The work was supported by a NovoNordisk STAR postdoc fellowship and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme. Read… Read More »Collaboration with NovoNordisk