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Tom’s Artwork Featured on RSC Chem Bio’s Cover

We were delighted when Tom Smith’s artwork was chosen for the front cover of the RSC’s Chemical Biology journal in January 2024!   About the artwork: “When deciding how best to summarise the work from our paper into some art we were thinking about the themes of developing cyclic peptide hits using experimental vs bioinformatic guided data. It just so happens that at the end of 2023, Newcastle University’s Glassblowing team ran a series of festive glassblowing workshops to raise funds for Newcastle Hospital Charity. There we encountered some incredible glass designs, including a hand made from glass, by our talented glass blower Robyn Hare (Newcastle University Research Facilities). We thought… Read More »Tom’s Artwork Featured on RSC Chem Bio’s Cover

Collaboration with NovoNordisk

Delighted to share the first publication of our collaboration with Martin Munzel and colleagues at NovoNordisk ‘An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor‘. Thanks to all involved: Bhaskar Bhushan, Daniele Granata, Christian S. Kaas, Marina A. Kasimova, Qiansheng Ren, Christian N. Cramer,  Mark D. White, Ann Maria K. Hansen,Christian Fledelius, Gaetano Invernizzi,Kristine Deibler, Oliver D. Coleman, Xin Zhao, Xinping Qu, Haimo Liu, Silvana S. Zurmühl,b Janos T. Kodra, Akane Kawamura and Martin Münzel The work was supported by a NovoNordisk STAR postdoc fellowship and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme. Read… Read More »Collaboration with NovoNordisk

New Epigenetics Paper by Roman Belle and Team

Congratulations to Roman Belle on the publications of ‘Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins‘. We are very happy to have published this work in great collaboration between academic groups in the UK, the Netherlands, Spain and Denmark. Thanks to all involved: Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield & Jasmin Mecinović. The work was supported by the European Research Council, Cancer Research UK, EPSRC, Clarendon Scholarship, the Netherlands Organization for Scientific Research, the Spanish MINECO, and a World Bank Education… Read More »New Epigenetics Paper by Roman Belle and Team

Paper in Epigenetics

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Paper in Epigenetics: Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications – Collaborative work with Chris Schofield, Louise Walport, James McCullagh, Richard Hopkinson and Emily Flashman groups where we report the use of LCMS based intact histone assay to look at the global changes in histone PTMs in response to hypoxia / compound treatment – read the full paper here  

Paper in JBC

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Paper in JBC – Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction. Our latest paper on the development of anti-inflammatory peptides inspired by tick evasins is out now in Journal of Biological Chemistry.  Multi-disciplinary collaborative work with Prof. Shoumo Bhattacharya & Prof. Carol Robinson Groups, with Benoit Darlot & James Eaton from the group leading the study. This work was funded by the BHF, Oxford BHF Centre for Research Excellence and SBM.

Paper in Oncogene

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Paper in Oncogene – Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. Our collaborative work with Dr Nathan Lack’s laboratory (Koç University / Turkey and Vancouver Prostate Centre /Canada) is finally out! Hilal Saraç has led this study on how KDM3B has been identified to be important in the proliferation of castrate resistant prostate cancers. This work was funded by the Royal Society Newton Advance Fellowship. Hilal’s beautiful waterfall plot figure – epigenetic shRNA library screening identifies KDM3B (red) to be essential for CRPC proliferation