STEM for BRITAIN, Houses of Parliament, London, UK (09/03/2020). Benoit Darlot presented his poster “TherapeuTick: from tick saliva to anti-inflammatory peptides” to MPs and their guest at this prestigious event showcasing each year the finest research produced in UK universities. He had the honour to discuss his research with Chi Onwurah, MP for Newcastle Central. (blog: B.D)
Attendance at the Gordon Research Conference on Chemistry and Biology of Peptides 2020 in Ventura, CA, USA. (9-14/02/2020) Benoit Darlot presented his work on tick saliva protein inspired anti-inflammatory peptides to the peptide community in Ventura. Great opportunity to share the lab’s work and get inspiration from the growing peptide community. (Blog by B.D.)
Chemical biology labs were officially handed over to us last week. Thank you to the Newcastle team (including Technical Team, Estates, Procurement, Management, the contractors) for their enormous effort to set up these labs in the Bedson building. Very excited to move in and start setting up the labs!
Vincent Saverat, a visiting student from Paris Sciences et Lettres University, joins our lab for a 5 month internship to work on epigenetics chemical probes development. Welcome Vincent!
I was delighted to attend the 2020 International Symposium on Chemical Biology in Geneva from 22–24 January and to represent the Kawamura and Schofield groups. With over 200 researchers in attendance, including 15 international leaders in science from all over the world, the conference was an outstanding success. It was exciting to be among such a varied group of scientists, all working under the ever-growing umbrella of chemical biology. The talks, presentations and lively discussions covered a wide variety of interesting topics such as biosynthesis and genetic code expansion. These have broadened my perspective and made me even more excited about being a chemical biologist. It was an honour to… Read More »Joanna at the 2020 International Symposium on Chemical Biology in Geneva
A book chapter with Prof. Shoumo Bhattacharya “Using evasins to target the chemokine network in inflammation” published in Advances in Protein Chemistry and Structural Biology is out now.
Delighted to contribute two chapters in Chemical Epigenetics in Topics in Medicinal Chemistry book series edited by Prof. Antonello Mai. Our review on “Inhibitors of JmjC-containing Histone Demethylases” by Miranda Wright, together with Prof. Paul Brennan (Target Discovery Institute, Oxford), focuses on the recent advances in JmjC-KDM inhibitor development from a structural perspective. In “Chemical Compounds Targeting DNA Methylation and Hydroxymethylation” by Roman Bell, together with Dr Paola Arimondo (Institut Pasteur, Paris), we review the recent developments in DNMT and TET inhibitors.
I was very pleased to have the opportunity to talk at the CBBG forum in Leicester at the Institute of Structural and Chemical Biology, very well co-organised by former Oxford colleague Richard Hopkinson. I spoke about our work on cyclic peptides binding to PHD2, as published in Chemical Science, and some more recent follow-up work. This was a great meeting; an excellent day of Chemical Biology talks and posters, as well as a chance to network, catching up with some people I already knew and making some new contacts. (Blog by Tom McAllister)
Paper in Oncogene – Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. Our collaborative work with Dr Nathan Lack’s laboratory (Koç University / Turkey and Vancouver Prostate Centre /Canada) is finally out! Hilal Saraç has led this study on how KDM3B has been identified to be important in the proliferation of castrate resistant prostate cancers. This work was funded by the Royal Society Newton Advance Fellowship. Hilal’s beautiful waterfall plot figure – epigenetic shRNA library screening identifies KDM3B (red) to be essential for CRPC proliferation
We enjoyed our traditional Kawamura-Flashman Group joint Christmas lunch