Emma won an RSC CBBG travel grant which enabled her to visit the lab of our collaborator Professor Frances Platt (Department of Pharmacology) in Oxford for two weeks in January 2023. The visit enabled Emma to test her cyclic peptide compounds in next stage assay models including against mouse brain homogenates and cell lysates. This enabled cross-screening against different isoenzymes of the disease target for selectivity studies, helping accelerate hit compound progression for lysosomal disorders and neurodegenerative therapy. As well as advancing the PhD, the visit helped strengthen collaborations with a world-leading laboratory in the disease field, with future collaborative work already in place in the coming months. Image Description(… Read More »Emma Wins RSC CBBG Travel Grant
Our group member Klemensas Simelis based at Oxford University handed in his thesis this week. Klem’s research looked at the “Development of Chemical Tools for Ten-Eleven Translocation Enzymes”. A summary of his project follows: Methylation of DNA (5-methylcytosine) is an epigenetic mark that typically silences gene expression. Ten-Eleven Translocation enzymes (TETs) oxidise the methyl groups of 5-methylcytosine, forming epigenetic DNA marks with distinct functions and facilitating DNA demethylation by other cellular mechanisms, which restores gene expression. The work discussed in the thesis is focused on: i) broadening the understanding of how these enzymes work using biochemical assays to detect catalytic activity, and ii) developing small molecule and cyclic peptide TET inhibitors… Read More »Thesis hand in day for Klem!
Delighted to share the first publication of our collaboration with Martin Munzel and colleagues at NovoNordisk ‘An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor‘. Thanks to all involved: Bhaskar Bhushan, Daniele Granata, Christian S. Kaas, Marina A. Kasimova, Qiansheng Ren, Christian N. Cramer, Mark D. White, Ann Maria K. Hansen,Christian Fledelius, Gaetano Invernizzi,Kristine Deibler, Oliver D. Coleman, Xin Zhao, Xinping Qu, Haimo Liu, Silvana S. Zurmühl,b Janos T. Kodra, Akane Kawamura and Martin Münzel The work was supported by a NovoNordisk STAR postdoc fellowship and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme. Read… Read More »Collaboration with NovoNordisk
A virtual CRUK Programme Meeting took place on Friday 10th December 2021. Great to get an overview of CRUK work across the Kawamura Group at Newcastle and the Schofield group at Oxford and set some goals for our research in 2022. Some engaging discussions on the latest developments in the field and a useful workshop on manuscripts to finish the meeting. Looking forward to getting together in person next time hopefully!
A double congratulations is owed to our own Dr Joanna Bonnici, who successfully navigated the perils of a pandemic-Zoom viva to defend her DPhil thesis in December. With hardly a breath to spare she started a family with her husband Tom, as baby Elsie arrived in late January this year. Joanna has been an asset to the lab throughout her DPhil and is almost certainly, definitely, looking forward to more happy years of research to come… Many congratulations to them all and we look forward to using both events as an excuse to over-celebrate later this year once we are all vaccinated!
After a few long days of packing the labs in Oxford, it was lovely to see so many people from the CRL come together for a few drinks and a relax at the Oxford Wine Café – including old group members – thank you for joining us!
Many Congratulations to Roman Belle for successfully defending his DPhil thesis titled “Histone Lysine and DNA Methylation: Dynamic Marks in the Chromatin”! Thanks to Dr Paola Arimondo from Institute Pasteur and James McCullagh for being his examiners.
Start of the new academic year! Welcome to Kieran Thow who joined our group as a MChem Part II student.