A warm welcome to Harriet Stanway-Gordon who started in the group this month. Harriet undertook her PhD with Prof. Mike Waring in the Medicinal Chemistry group at Newcastle, focusing on the development of micellar-mediated DNA-compatible chemistry for use in DNA-encoded library (DEL) synthesis, where she was involved in the development and optimisation of multiple classes of reactions. Through the application of this methodology, a proposed new class of drug molecules, termed cyclic peptide small molecule hybrids (CyPeMs) can now be constructed within DELs.
Harriet has been awarded an EPSRC doctoral prize to expand upon her PhD research, involving the synthesis of CyPeM DELs and subsequent selection against several challenging epigenetic protein families to allow for rapid identification of active compounds from this novel class.